Studies
We perform internal cohort analyses based on Whole Genome Sequencing (WGS) microbiome data, Health & Diet Intake Data, and Formulation Data to assess the efficacy of our personalized products for individuals and cohort populations.
Irritable Bowel Syndrome (IBS)
IBS is a prevalent, complex, chronic condition affecting approximately 10% of the global population. It is characterized by symptoms such as abdominal pain, bloating, and altered bowel habits, significantly impacting patients' quality of life. A notable aspect of IBS is dysbiosis, characterized by reduced microbial diversity, a lack of beneficial bacteria, and an increase in pro-inflammatory bacteria.
Constipation
Between 15% to 20% of adults and up to 33% of adults over the age of 60 years old are affected by chronic constipation. The frequency of bowel movements in constipation is fewer than 3 bowel movements per week. Symptoms include sensation of straining, lumpy or hard stools, feeling of incomplete evacuation, anorectal obstruction, or blockage, and may require manual maneuvers to facilitate bowel movement.
2024.08.27
Diarrhea
Diarrhea is a common gastrointestinal condition affecting up to 5% of the population. It is characterized by the frequent passage of loose or watery stools and can result from a variety of factors, including infections, dietary factors including food intolerances, medication side effects, or chronic diseases. There are significant impacts on the quality of life in individuals with diarrhea, some of which are dehydration risk, nutritional impact, and health complications.
2024.08.28
Research Publications
We collaborate with well known researchers and institutions to provide knowledge regarding the utility of our products in meeting specific wellness requirements.
Precision synbiotics increase gut microbiome diversity and improve gastrointestinal symptoms in a pilot open-label study for autism spectrum disorder
Following the 3-month synbiotic supplementation, the ASD cohort showed increased taxonomic alpha diversity, shifts in taxonomy and metabolic pathway potential, and improvements in some ASD-related symptoms, including a significant reduction in GI discomfort and overall improved language, comprehension, cognition, thinking, and speech.
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Alterations in Gut Microbiome Composition and Function in Irritable Bowel Syndrome and Increased Probiotic Abundance with Daily Supplementation
Longitudinal assessment of 134 IBS subjects receiving synbiotic supplements demonstrated a significant difference in microbial features and an increase in probiotic abundance across time. We identified microbial features that differentiate healthy and IBS subtypes. Synbiotic supplementation in IBS subjects did not result in alpha diversity change in the microbiome but did demonstrate changes in microbial features.
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